of Neurobiology, created in 1996, is established at the Alfort School of
Veterinary Medicine, near Paris.
The Laboratory belongs to the
team “Biology of the neuromuscular system” (BNMS), part of the ESPRY research
department of Institut Mondor de Recherche Biomédicale (IMRB), directed by the
professor Frederic Relaix. The BNMS has been created in January 2015 by the
fusion of five groups from the UPE-C, INSERM and EnvA, and is also associated
with CNRS and EFS.
The BNMS’s first
objective is to describe neuromuscular diseases. To identify the genetic or
environmental origin of these diseases, to understand the pathogenic mechanisms
that underlie them, at the molecular, cellular or systemic level. The molecular
characterization integrated on the scale of the whole organism makes possible
to identify new genetic, cellular or pharmacological tools with a therapeutic
second objective of the BNMS is to evaluate the reliability of innovative
therapeutic tools for neuromuscular diseases by integrating the preclinical and
clinical phases of the evaluation of the efficacy and safety of these therapeutic
tools in the same team, first in animals and then in patients.
aims of the Laboratory of Neurobiology are to study
canine and feline neuromuscular diseases and to
evaluate therapeutic benefits provided by new
strategies involving pharmacological, genic or cellular tools that
had already showed encouraging results in in
vitro experiments or on small animal models.
order to accomplish this delicate work,
the Laboratory of Neurobiology has established a
platform of therapeutic assays associated with an
intensive care unit allowing the
medical maintenance of sick animals.
subventions, and in particular the
permanent support of the AFM, the laboratory has considerable
resources. Indeed, about twenty people coming from various horizons
researcher, engineers, technicians of research and animal house
collaborate on a daily basis.
its competences and its experiences, the
Laboratory of Neurobiology occupies a choice place in the
international scientific landscape:
it’s one of the few teams having the handiness of large-size
models and it develops multiple collaborations with high scientific
the Laboratory of Neurobiology contributes to a quality teaching taking mainly part in the
training of the Alfort School of Veterinary Medicine.