publications

2017

Le Guiner C Servais L Montus M Larcher T Fraysse B, Moullec S, Allais M, Francois V, Dutilleul M, Malerba A, Koo T, Thibaut J.L, Matot B, Devaux M, LeDuff J, Deschamps J.Y, Barthélémy I, Blot S, Testault I, Wahbi K, Ederhy S, Martin S, Veron P, Georger C, Athanasopoulos T, Masurier C, Mingozzi F, Carlier P, Gjata B, Hogrel J.Y, Adjali O, Mavilio F, Voit T, Moullier P, Dickson G. Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy. Nat.Commun. 2017, Jul 25.

Fraysse B, Barthélémy I, Qannari EM, Rouger K, Thorin C, Blot S, Le Guiner C, Chérel Y, Hogrel JY. Gait characterization in golden retriever muscular dystrophy dogs using linear discriminant analysis. BMC Musculoskelet Disord. 2017, Apr 12.

Thibaud JL, Matot B, Barthélémy I, Fromes Y, Blot S, Carlier P.Anatomical and mesoscopic characterization of the dystrophic diaphragm: An in vivo nuclear magnetic resonance imaging study in the Golden retriever muscular dystrophy dog. Neuromuscul Disord. 2017, Feb 7.

2016

Palazzolo G, Quattrocelli M, Toelen J, Dominici R, Anastasia L, Tettamenti G, Barthelemy I, Blot S, Gijsbers R, Cassano M, Sampaolesi M (2016). Cardiac Niche Influences the Direct Reprogramming of Canine Fibroblasts into Cardiomyocyte-Like Cells. Stem Cells Int. 2016, 4969430-

2015

Quattrocelli M, Swinnen M, Giacomazzi G, Camps J, Barthelemy I, Ceccarelli G, Caluwe E, Grosemans H, Thorrez L, Pelizzo G, Muijtjens M, Verfaillie CM, Blot S, Janssens S, Sampaolesi M (2015). Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle. J.Clin.Invest. 125, 4463-4482.

Blondelle J, Ohno Y, Gache V, Guyot S, Storck S, Blanchard-Gutton N, Barthelemy I, Walmsley G, Rahier A, Gadin S, Maurer M, Guillaud L, Prola A, Ferry A, Aubin-Houzelstein G, Demarquoy J, Relaix F, Piercy RJ, Blot S, Kihara A, Tiret L, Pilot-Storck F. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. J.Mol.Cell Biol. 2015. 7, 429-440.

2014

Barthélémy I, Pinto-Mariz F, Yada E, Desquilbet L, Savino W, Silva-Barbosa SD, Faussat AM, Mouly V, Voit T, Blot S, Butler-Browne G. Predictive markers of clinical outcome in the GRMD dog model of Duchenne muscular dystrophy. Dis Model Mech. 2014 Nov;7(11).

Jeanson-Leh L, Lameth J, Krimi S, Buisset J, Amor F, Le GC, Barthelemy I, Servais L, Blot S, Voit T, Israeli D (2014). Serum profiling identifies novel muscle miRNA and cardiomyopathy-related miRNA biomarkers in Golden Retriever muscular dystrophy dogs and Duchenne muscular dystrophy patients. Am.J.Pathol. 184, 2885-2898.

La Rovere RM, Quattrocelli M, Pietrangelo T, Di Filippo ES, Maccatrozzo L, Cassano M, Mascarello F, Barthelemy I, Blot S, Sampaolesi M, Fulle S (2014). Myogenic potential of canine craniofacial satellite cells. Front Aging Neurosci. 6, 90-

2012

Barthélémy I, Uriarte A, Drougard C, Unterfinger Y, Thibaud JL, Blot S. Effects of an immunosuppressive treatment in the GRMD dog model of Duchenne muscular dystrophy PLoS One. 2012 Nov 21:7 (11).

Vulin A, Barthélémy I, Goyenvalle A, Thibaud JL, Beley C, Griffith G, Benchaouir R, le Hir M, Unterfinger Y, Lorain S, Dreyfus P, Voit T, Carlier P, Blot S, Garcia L. Muscle function recovery in golden retriever muscular dystrophy after AAV1-U7 exon skipping. Mol Ther. 2012 Nov;20 (11).

Thibaud JL, Azzabou N, Barthelemy I, Fleury S, Cabrol L, Blot S, Carlier PG. Comprehensive longitudinal characterization of canine muscular dystrophy by serial NMR imaging of GRMD dogs. Neuromuscul Disord. 2012 Oct1;22 Suppl 2.

Bedu AS, Labruyère JJ, Thibaud JL, Barthélémy I, Leperlier D, Saunders JH, Blot S. Age-related thoracic radiographic changes in golden and labrador retriever muscular dystrophy. Vet Radiol Ultrasound. 2012 Sep-Oct;53(5).

Su JB, Cazorla O, Blot S, Blanchard-Gutton N, Ait Mou Y, Barthélémy I, Sambin L, Sampedrano CC, Gouni V, Unterfinger Y, Aguilar P, Thibaud JL, Bizé A, Pouchelon JL, Dabiré H, Ghaleh B, Berdeaux A, Chetboul V, Lacampagne A, Hittinger L. Bradykinin restores left ventricular function, sarcomeric protein phosphorylation, and e/nNOS levels in dogs with Duchenne muscular dystrophy cardiomyopathy. Cardiovasc Res. 2012 Jul 1;95(1):86-96.

Maurer M, Mary J, Guillaud L, Fender M, Pele M, Bilzer T, N. Olby, Penderis J, Shelton GD, Panthier JJ, Thibaud JL, Barthelemy I, Aubin-Houzelstein G, Blot S, Hitte C, and Tiret L. Centronuclear myopathy in Labrador retrievers: a recent founder mutation in the PTPLA gene has rapidly disseminated worldwide. PLoS.One 2012; 7 (10).

H. Dabire, Barthelemy I, Blanchard-Gutton N, Sambin L, Sampedrano C. C.. Gouni V, Unterfinger Y, Aguilar P, Thibaud JL, Ghaleh B, Bize A, Pouchelon JL, Blot S, Berdeaux A, Hittinger L, Chetboul V, and Su JB. Vascular endothelial dysfunction in Duchenne muscular dystrophy is restored by bradykinin through upregulation of eNOS and nNOS. Basic Res.Cardiol. 2012 Jan; 107 (1):240.

2011

Barthelemy I, E. Barrey, Aguilar P, Uriarte A, Chevoir M. Le, Thibaud JL, T. Voit, Blot S, and Hogrel JY. Longitudinal ambulatory measurements of gait abnormality in dystrophin-deficient dogs. BMC.Musculoskelet.Disord 2011; 12:75. PMID:21489295

2010

Uriarte A, Moissonnier P, Thibaud JL, E. Reyes-Gomez, P. Devauchelle, and Blot S Surgical treatment and radiation therapy of frontal lobe meningiomas in 7 dogs. Can.Vet.J. 2010; 52 (7):748-752. PMID:22210938

S. Laurent, Thibaud JL., J. Hordeaux, Reyes-Gomez E, Delisle F, Blot S, and Colle MA. Chronic traumatic brain injury in a dog. J.Comp Pathol.  2010; 143 (1):75-80.  PMID:20106486

Uriarte A, Thibaud JL, Blot S. Botulism in 2 urban dogs. Can Vet J. 2010 Oct:1139-42. PMID:21197207

2009

A. Uriarte, J-L. Thibaud and S. Blot. Botulism in two urban dogs. Canadian veterinary journal. Article in Press, 2009.

A. Uriarte, P. Moissonnier, J-L. Thibaud, E. Reyes-Gomez, P. Devauchelle and S. Blot. Surgical treatment and radiation therapy of frontal lobe meningiomas in 7 dogs. Canadian veterinary journal. Article in Press, 2009.

I. Barthélémy, E. Barrey, J-L. Thibaud, A. Uriarte, T. Voit, S. Blot and J-Y Hogrel. Gait analysis using accelerometry in dystrophin-deficient dogs. Neuromuscul Disord. 19(11):788-96, 2009. PMID: 19800232.

2008

S. Belluco, J. L. Thibaud, J. Guyot, M. B. Krockenberger, M. Wyers, S. Blot and M. A. Colle. Spinal cryptococcoma in an immunocompetent Cat. Journal of Comparative Pathology.  139 (4):246-251, 2008. PMID: 18783789

J. L. Thibaud, A. Hidalgo, G. Benchekroun, L. Fanchon, F. Crespeau, F. Delisle, and S. Blot. Progressive myelopathy due to a spontaneous intramedullary haematoma in a dog: pre-and post-operative clinical and magnetic resonance imaging follow-up. J.Am. Anim. Hosp. Assoc. 44(5): 266-275, 2008. PMID: 18762564

J. L. Thibaud and S. Blot. Diagnostic de myopathie chez le Chien. Pratique Vet. 43: 186-189, 2008.

2007

N. Granger, A. Hidalgo, D. Leperlier, K. Gnirs, J. L. Thibaud, F. Delisle, and S. Blot. Successful treatment of cervical spinal epidural empyema in a cat secondary to grass awn migration. J.Feline Med.Surg. 9: 340-345, 2007.  PMID: 17449314

J. L. Thibaud, A. Monnet, D. Bertoldi, I. Barthelemy, S. Blot, and P. G. Carlier. Characterization of dystrophic muscle in Golden Retriever Muscular Dystrophy dogs by nuclear magnetic resonance imaging. Neuromuscul.Disord. 17: 575-584, 2007.  PMID: 17537632

J. L. Thibaud, L. Tiret and S. Blot. Le dépistage des maladies neuromusculaires d’origine génétique chez le chien et le chat. Le nouveau praticien vétérinaire. 121-129, 2007.

2006

S. Blot, M. Sampaolesi, G. D'Antona, N. Granger, R. Tonlorenzi, A. Innocenzi, P. Mognol, J. L. Thibaud, B.Galvez, I. Barthelemy, L. Perani, S. Mantero, M. Guttinger, O. Pansarasa, C. Rinaldi, Angelis G. Cusella-De, I. Torrente, C. Bordignon, R. Botinelli, and G. Cossu. Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs. Nature 444(7119): 574-579, 2006. PMID: 17108972

V. Chetboul, S. Blot, C. Carlos, J. L. Thibaud, N. Granger, R. Tissier, P. Bruneval, F. Gaschen, V. Gouni, A. Nicolle, and J. L. Pouchelon. Tissue Doppler imaging for detection of radial and longitudinal myocardial dysfunction in a family of cats affected by dystrophin-deficient hypertrophic muscular dystrophy. J.Vet.Intern.Med. 20 (3):640-647, 2006. PMID: 16734102

N. Granger, P. Moissonnier, L. Fanchon, A. Hidalgo, K. Gnirs, and S. Blot. Cutaneous saphenous nerve graft for the treatment of sciatic neurotmesis in a dog. J.Am.Vet.Med.Assoc. 229(1): 82-86, 2006.  PMID: 16817718

S. Perie, K. Mamchaoui, V. Mouly, S. Blot, B. Bouazza, L. E. Thornell, J. Lacau Saint Guily, and G. S. Butler-Browne. Premature proliferative arrest of myoblasts in oculo-pharyngeal muscular dystrophy: therapeutic perspective of autologous myoblast transplantation. Neuromuscul.Disord. 16(11): 770-781, 2006.  PMID: 17005403

2005

S. Blot. Myopathies des carnivores domestiques. Encycl.Vétérinaire Neurologie 2100: 1-16, 2005.

S. Blot and D. Tessier-Vetzel. Echographie du système nerveux. In: Echographie et doppler du chien et du chat, edited by V. Chetboul (Masson), 439-447, 2005.

N. Granger, J. L. Thibaud, and S. Blot. Les indications de l'IRM en neurologie. Le Point Vétérinaire 252(36): 68-73, 2005.

P. Moissonnier, V. Cuvilliez, A. Klein, C. Carozzo, C. Escriou, K. Gnirs, S. Blot, and A. Hidalgo. Restoration of elbow flexion by performing contralateral lateral thoracic and thoracodorsal nerve transfers after experimental musculocutaneous nerve transection. J.Neurosurg. 103 (1):70-78, 2005. PMID: 16121976

M. Pele, L. Tiret, J. L. Kessler, S. Blot, and J. J. Panthier. SINE exonic insertion in the PTPLA gene leads to multiple splicing defects and segregates with the autosomal recessive centronuclear myopathy in dog. Hum.Mol.Genet. 14(11): 1417-1427, 2005.  PMID: 15829503

2004

S. Blot. Diseases of skeletal muscles. In: Textbook of Veterinary Internal Medicine, edited by S.J. Ettinger and E.C. Feldman (W. B. Saunders), 901-905, 2004.

V. Chetboul, C. Carlos, S. Blot, J. L. Thibaud, C. Escriou, R. Tissier, J. L. Retortillo, and J. L. Pouchelon. Tissue Doppler assessment of diastolic and systolic alterations of radial and longitudinal left ventricular motions in Golden Retrievers during the preclinical phase of cardiomyopathy associated with muscular dystrophy. Am.J.Vet.Res. 65(10): 1335-1341, 2004. PMID: 15524319

V. Chetboul, C. Escriou, D. Tessier, V. Richard, J. L. Pouchelon, H. Thibault, F. Lallemand, C. Thuillez, S. Blot, and G. A. Derumeaux. Tissue Doppler imaging detects early asymptomatic myocardial abnormalities in a dog model of Duchenne's cardiomyopathy. Eur.Heart J. 21(25): 1934-1939, 2004. PMID: 15522473

V. Chetboul, D. Tessier, C. Escriou, R.Tissier, C. Carlos, M. Boussouf, J.L. Pouchelon , S. Blot, and G. A. Derumeaux. Diagnostic potential of natriuretic peptides in the occult phase of Golden Retriever Muscular Dystrophy (GRMD) cardiomyopathy. J Vet Intern Med 2004, 18: 845-850. PMID: 15638268

N. Olby, S. Blot, J. L. Thibaud, J. Phillips, D. P. O'Brien, J. Burr, J. Berg, T. Brown, and M. Breen. Cerebellar cortical degeneration in adult American Staffordshire terriers. J.Vet.Intern.Med. 18(2): 201-208, 2004. PMID: 15058771

2003

K. Gnirs, Y. Ruel, S. Blot, D. Begon, D. Rault, F. Delisle, L. Boulouha, M-A. Colle, C. Carozzo, and P. Moissonnier. Spinal subarachnoid cysts in 13 dogs: imaging and surgical investigations. Vet. Radiol. Ultrasound 44(4): 402-408, 2003. PMID: 12939056

J. L. Thibaud and S. Blot. Observation clinique: le syndrome vestibulaire chez un chien. Le Nouveau Praticien Vétérinaire 11: 37-43, 2003.

L. Tiret, S. Blot, J. L. Kessler, H. Gaillot, M. Breen, and J. J. Panthier. The cnm locus, a canine homologue of human autosomal forms of centronuclear myopathy, maps to chromosome 2. Hum.Genet. 113(4): 297-306, 2003. PMID: 12884002

2002

P. Moissonnier, S. Blot, P. Devauchelle, F. Delisle, F. Beuvon, L. Boulouha, M-A. Colle, and T Lefrançois. Stereotactic CT-guided brain biopsy in the dog. J.Small Anim.Pract. 43(3): 115-123, 2002. PMID: 11916055

C. Thioudellet, S. Blot, P. Squiban, M. Fardeau, and S. Braun. Current protocol of research phase I clinical trial of full-length dystrophin plasmid DNA in Duchenne/Becker muscular dystrophies Part I: rationale. Neuromuscul.Disord. 12 (Supl.1): S49-S51, 2002. PMID: 12206795

2001

W. A. Beltran, S. Chahory, K. Gnirs, C. Escriou, S. Blot, and B. Clerc. The electroretinographic phenotype of dogs with Golden Retriever Muscular Dystrophy. Vet.Ophthalmol. 4(4): 277-282, 2001.